Catherine Rivier

Professor, Salk Institute for Biological Studies
Ph.D., University of Lausanne, Switzerland, 1972
crivier@salk.edu

Selected Recent Publications

Turnbull AV and Rivier CL. 1999 Regulation of the hypothalamo-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiol. Rev. 79:1-71.

Turnbull AV, Vaughan J, Rivier JE, Vale WW and Rivier C. 1999 Urocortin is not a significant regulator of intermittent electrofootshock-induced ACTH secretion in the intact male rat. Endocrinology 140:71-78.

Rivier C. 1999 Alcohol rapidly lowers plasma testosterone levels in the rat: Evidence that a neural brain-gonadal pathway may be important for decreased testicular responsiveness to gonadotropin. Alcoholism: Clin Exp Res 23:38-45.

Turnbull AV, Smith GW, Lee S, Vale WW, Lee K-F and Rivier C. 1999 CRF type I receptor-deficient mice exhibit a pronounced pituitary-adrenal response to local inflammation. Endocrinology 140:1013-1017.

Kim CK, Turnbull AV, Lee S and Rivier CL. 1999 Effects of prenatal exposure to alcohol on the release of ACTH, corticosterone and pro-inflammatory cytokines. Alcoholism: Clin Exp Res 23:52-59.

Rivier C. 1999 Effect of acute alcohol treatment on the release of ACTH, corticosterone and pro-inflammatory cytokines in response to endotoxin. Alcoholism: Clin Exp Res 23:673-682.

Rivier C. 1999 Gender, sex steroids, corticotropin-releasing factor, nitric oxide and the HPA response to stress. Pharmacol Biochem Behav 64:739-751.

Uribe RM, Lee S and Rivier C. 1999 Endotoxin stimulates nitric oxide production in the paraventricular nucleus of the hypothalamus through nitric oxide synthase I: Correlation with HPA axis activation. Endocrinology 140:5971-5981.

Lee S, Kim CK and Rivier C. 1999 Nitric oxide stimulates ACTH secretion, as well as the transcription of the genes encoding for corticotropin-releasing factor, corticotropin-releasing factor receptors type 1 and vasopressin in the hypothalamus of the intact rat. J Neurosci 19:7640-7647.

Rivier JE, Kirby DA, Lahrichi SL, Corrigan A, Vale WW and Rivier CL. 1999 Constrained corticotropin releasing factor (CRF) antagonists (Astressin analogues) with long duration of action in the rat. J Med Chem 42:3175-318.

Lee S and Rivier C. 1999 Role of nitric oxide and carbon monoxide in modulating the response of the rat hypothalamic pituitary-adrenal axis to immune challenges. In: Control Mechanisms of Stress and Emotion: Neuroendocrine-Based Studies. H Yamashita, JW Funder, JG Verbalis, Y Ueta and Y Endo, eds. pp. 155-163.

Lee S, Schmidt D, Tilders F, Cole M, Smith A and Rivier C. 2000 Prolonged exposure to intermittent alcohol vapors blunts hypothalamic responsiveness to immune and non-immune signals. Alcoholism: Clin Exp Res 24:110-122.

Rivier JE, Struthers RS, Porter J, Lahrichi SL, Jiang G, Cervini LA, Ibea M, Kirby DA, Koerber SC and Rivier CL. 2000 Design of potent dicyclic (4-10/5-8) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem 43:784-796.

Rivier JE, Porter J, Cervini LA, Lahrichi SL, Kirby DA, Struthers RS, Koerber SC and Rivier CL. 2000 Design of monocyclic (1-3) and dicyclic (1-3/4-10) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem 43:797-806.

Rivier JE, Jiang G, Struthers RS, Koerber SC, Porter J, Cervini LA, Kirby DA, Craig AG and Rivier CL. 2000 Design of potent dicyclic (1-5/4-10) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem 43:807-818.

Kim CK and Rivier CL. 2000 Nitric oxide and carbon monoxide have a stimulatory role in the hypothalamic-pituitary-adrenal response to physico-emotional stressors in rats. Endocrinology 2000, 141, 2244-2253.

Lee S, Schmidt D, Tilders F and Rivier C. 2000 Increased activity of the hypothalamic-pituitary-adrenal axis of rats exposed to alcohol in utero: Role of altered pituitary and hypothalamic function. Mol Cell Neurosci 16:515-528.

Rivier C. 2000 Effects of alcohol on the neuroendocrine system. In: Review of NIAAA's Neuroscience and Behavioral Research Portfolio. National Institute on Alcohol Abuse and Alcoholism Research, Bethesda, MD. NIAAA Research Monograph No. 34 61-81.

Lopez-Figueroa MO, Day HEW, Lee S, Rivier C, Akil H and Watson SJ. 2000 Temporal and anatomical distribution of nitric oxide synthase mRNA expression and nitric oxide production during central nervous system inflammation. Brain Res 852:239-246.

Rivier C. 2001 The hypothalamic-pituitary-adrenal axis response to immune signals. In: Psychoneuroimmunology. Ader R, Felten DL and Cohen N, eds. San Diego, CA: Academic Press, pp 633-648.

Rivier C. 2001 Relative importance of nitric oxide and carbon monoxide in regulating the ACTH response to immune and non-immune signals. Stress 4:13-24.

Rivier C. 2001 Does IL-6 release ACTH by exerting a paracrine role in the rat anterior pituitary? Stress 4:39-55.

Rivier C. 2001 Role of gaseous neurotransmitters in the HPA axis. In: The Role of Neural Plasticity in Chemical Intolerance. New York Academy of Sciences: New York, NY. vol. 933, 254-264.

Rivier C. 2001 The hypothalamic-pituitary-adrenal axis response to immune signals. In: Ader R, Felten DL, Cohen N (eds) Psychoneuroimmunology, Third Edition, Chapter 24 ed. Academic Press, San Diego, CA, pp 633-648.

Lee S, Schmidt ED, Tilders FJH and Rivier C. 2001 Effect of repeated exposure to alcohol on the response of the hypothalamic-pituitary adrenal axis of the rat: I. Role of changes in hypothalamic neuronal activity. Alcoholism: Clin Exp Res 25:98-105.

Lee S, Smith G, Vale W, Lee K-F and Rivier C. 2001 Mice that lack corticotropin-releasing factor (CRF) receptors type 1 show a blunted ACTH response to acute alcohol despite up-regulated constitutive hypothalamic CRF gene expression. Alcoholism: Clin Exp Res 25:427-433.

Seo DO and Rivier C. 2001 Microinfusion of a nitric oxide donor in discrete brain regions activates the hypothalamic-pituitary axis. J Neuroendocrinol 13:925-933.

Seo D, Lee S and Rivier C. 2002 Comparison between the influence of the intravenous and intracerebroventricular injection of a nitric oxide donor on ACTH release and hypothalamic neuronal activity. J Neuroendocrinol 14:568-573.

Rivier C. 2002 Role of nitric oxide and carbon monoxide in modulating the activity of the rodent hypothalamic-pituitary-adrenal axis. In: Neuroendocrine-Immune Interactions: Frontiers of Hormone Research. S. Karger AG, Basel, London, vol. 29, 15-49.

Lee S, Miselis R and Rivier C. 2002 Anatomical and functional evidence for a neural hypothalamic-testicular pathway that is independent of the pituitary. Endocrinology 143:4447-4454.

Rivier C, Grigoriadis D and Rivier J. 2003 Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat ACTH response to stressors. Endocrinology 144:2396-2403.

Rivier C. 2003 Role of nitric oxide in regulating the rat hypothalamic-pituitary-adrenal axis response to endotoxemia. In: Neuroendocrine and Neural Regulation of Autoimmune and Inflammatory Disease: Molecular, Systems, and Clinical Insights, Sternberg, E.M., Haour, F.C., and Smith, C.C., eds. Ann NY Acad Sci 992:72-85.

Ryabinin AE, Bachtell RK, Heinrichs SC, Lee S, Rivier C, Olive MF, Mehmert KK, Camarini R, Kim JA, Koenig HN, Nannini MA, Hodge CW, Roberts AJ and Koob GF. 2002 The CRF/urocortin system and alcohol. Alcoholism: Clin Exp Res 26:714-722.

Lee S, Blanton CA and Rivier C. 2003 Prenatal ethanol exposure alters responsiveness of the rat hypothalamic-pituitary-adrenal axis to nitric oxide. Alcoholism: Clin Exp Res 27:962-969.

Selvage DJ and Rivier C. 2003 Importance of the paraventricular nucleus of the hypothalamus as a component of a neural pathway between the brain and the testes that modulates testosterone secretion independently of the pituitary. Endocrinology 144:594-598.

Lee S and Rivier C. 2003 Long-term influence of an initial exposure to alcohol on the rat hypothalamic-pituitary axis. Alcoholism: Clin Exp Res 27:1463-1470.

Selvage DJ, Lee SY, Parsons LH, Seo DO and Rivier CL. 2004 A hypothalamic-testicular neural pathway is influenced by brain catecholamines, but not testicular blood flow. Endocrinology 145:1750-1759.

Lee S, Selvage D and Rivier C. 2004 Site of action of acute alcohol administration in stimulating the rat hypothalamic-pituitary-adrenal axis: Comparison between the effect of systemic and intracerebroventricular injection of this drug on pituitary and hypothalamic responses. Endocrinology 145:4470-4479.

Seo DO, Lee S and Rivier CL. 2004 Comparison between the influence of shocks and endotoxemia on the activation of brain cells that contain nitric oxide. Brain Res 998:1-12.

Seo DO, Lee S and Rivier C. 2004 Prolonged exposure to intermittent alcohol vapors decreases the ACTH as well as hypothalamic nitric oxide and cytokine responses to endotoxemia. Alcoholism: Clin Exp Res 28:848-854.

Selvage DJ and Rivier C. 2004 Leydig cell activity is regulated by a neural pathway between the hypothalamus and the testes that does not include the pituitary. Recent Research Developments in Endocrinology; Transworld Research Network: Kerala, India, pp 97-114.

Lee S and Rivier C. 2005 Role played by hypothalamic nuclear factor-kB in alcohol-mediated activation of the rat hypothalamic-pituiatry-adrenal axis. Endocrinology 146:2006-2014.

Li Z, Kang SS, Lee S and Rivier C. 2005 Effect of ethanol on the regulation of corticotropin-releasing factor (CRF) gene expression. Mol Cell Neurosci 29:345-354

Samant MP, Gulyas J, Hong DJ, Croston G, Rivier C and Rivier J. 2005 Iterative approach to the discovery of novel degarelix analogues: substitutions at positions 3, 7 and 8. Part II. J Med Chem 48:4851-4860.

Samant MP, Hong DJ, Croston G, Rivier C and Rivier J. 2005 Novel gonadotropin-releasing hormone antagonists with substitutions at position 5. Biopolymers 80:386-391.

Samant MP, Hong DJ, Croston G, Rivier CL and Rivier JE. 2005 Synthesis and biological activity of GnRH antagonists modified at position 3 with 3-(2-methoxy-5-pyridyl)alanine. J Pept Res 65:284-291.

Samant MP, Gulyas J, Hong DJ, Croston G, Rivier C and Rivier J. 2005 Synthesis, in vivo and in vitro biological activity of novel azaline B analogs. Bioorg Med Chem Lett 15:2894-2897.

Herman M and Rivier C. 2006 Activation of a neural brain-testicular pathway lowers Leydig cells levels of the steroidogenic acute regulatory protein and the peripheral-type benzodiazepine receptor while increasing levels of neuronal nitric oxide synthase. Endocrinology 147:624-633.

Herman M, Kang SS, Lee S, James P and Rivier C. 2006 Systemic administration of alcohol to adult rats inhibits Leydig cell activity: Time-course of effect and role of nitric oxide. Alcoholism:  Clin Exp Res 30:1479-1491.

Richardson HN, Zorrilla EP, Mandyam CD and Rivier CL. 2006 Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood. Endocrinology 147:2506-2517.

Samant MP, Hong DJ, Croston G, Rivier C and Rivier J. 2006 Novel analogues of degarelix incorporating hydroxy-, methoxy- and pegylated- urea moieties at residues 3, 5, 6 and the N-terminus.  Part III. J Med Chem 49:3536-3543.

Selvage DJ, Parsons L and Rivier C. 2006 Role played by brain stem neurons in retulating testosterone secretion via a direct neural pathway between the hypothalamus and the testes. Endocrinology 147:3070-3075.

James P, Rivier C and Lee S. 2007 Presence of corticotrophin-releasing factor and/or tyrosine hydroxylase in cells of a neural brain-testicular pathway that are labelled by a transganglionic tracer. J Neuroendocrinol 20:173-181.

Rivier J, Gulyas J, Kunitake K, DiGruccio M, Cantle JP, Perrin MH, Donaldson C, Vaughan J, Million M, Gourcerol G, Adelson DW, Rivier C, Taché Y and Vale W. 2007 Stressin1-A, a potent corticotropin releasing factor Receptor 1 (CRF1)-selective peptide agonist. J Med Chem 50:1668-1674.

Rivier CL. 2008 Urocortin 1 inhibits rat leydig cell function. Endocrinology 149:6425-6432.  PMCID: PMC2613056

Choi IY, Lee S and Rivier C. 2008 Novel role of adrenergic neurons in the brain stem in mediating the hypothalamic-pituitary axis hyperactivity caused by prenatal alcohol exposure. Neuroscience 155:888-901. PMCID: PMC3174801.

Ji D, Gilpin NW, Richardson HN, Rivier CL and Koob GF. 2008 Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. Behav Pharmacol 19:1-12. PMCID: PMC2586833.

Maji SK, Schubert D, Rivier C, Lee S, Rivier JE and Riek R. 2008 Amyloid as depot for the formulation of long-acting drugs. PLoS Biol 6:E17. PMCID: PMC2225439.

Lee S, Choi I, Kang S and Rivier C. 2008 Role of various neurotransmitters in mediating the long-term endocrine consequences of prenatal alcohol exposure. Ann NY Acad Sci 1144:176-188. PMCID: PMC2796868.

Mandyam CD, Crawford EF, Eisch AJ, Rivier CL and Richardson HN. 2008 Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus. Dev Neurobiol 68:575-589.

Richardson HN, O'Dell LE, Lee SY, Koob GF and Rivier CL. 2008 Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. Eur J Neurosci 28:1641-1653. PMCID: PMC2748838.

Allen CD, Lee S, Koob GF and Rivier C. 2011 Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats. Brain, Behav Immun 25:S50-S60. PMCID: PMC3098294.

Allen CD, Rivier CL, Koob GF and Lee S. 2011 Adolescent alcohol exposure alters the central brain circuits known to regulate the stress response. Neuroscience 182:162-168. PMCID: PMC3085552.

Lee S, Braden B, Kang SS and Rivier C. 2011 Urocortins are present in the rat testis. Neuropeptides 45:131-137. PMCID: PMC3043384.

Wang L, Million M, Rivier J, Rivier C, Craft N, Stenzel-Poore MP and Tache Y. 2011 CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice. PLOS One 6:e16377. PMCID: PMC3040186.

Allen CD, Waser B, Körner M, Reubi JC, Lee S and Rivier C. 2011 Neuropeptide Y acts within the rat testis to inhibit testosterone secretion. Neuropeptides 45:55-61. PMCID: PMC3053052.